IL18 Reporter HEK-293 Cell Line

Description

Interleukin-18 (IL-18) is a cytokine with multiple functions, belonging to the IL-1 superfamily. It plays important roles in both innate and adaptive immunity by interacting with IL-12 to regulate interferon-gamma (IFN-γ) production in Th1 responses. IL-18 also induces the production of other cytokines, such as GM-CSF, TNF-α, IL-1β, enhancing the innate immune response.Initially identified as a factor inducing IFN-γ production in Th1 cells, IL-18, in the presence of IL-12, acts on non-polarized T cells, NK cells, NKT cells, B cells, DC cells, and macrophages to produce IFN-γ. Additionally, IL-18, in the absence of IL-12 but with IL-2, can induce CD4+ T cells, NK cells, even established Th1 cells to produce Th2 cell cytokines. IL-18 combined with IL-3 can induce mast cells and eosinophils to produce IL-4 and IL-13. Therefore, IL-18 stimulates both innate and adaptive immunity.The IL18 Reporter HEK-293 Cell Line, using HEK-293 as the host cell, is stably engineered to express IL-18R, IL-18Rap, and reporter genes through lentiviral infection. The bioactivity of IL-18 protein and related inhibitors can be quantified by generated luciferase. This cell line is useful for researching IL-18 related anti-tumor drugs.