Immortalized Human Alveolar Epithelial Cell Line

FOR RESEARCH USE ONLY

The Immortalized Human Alveolar Epithelial Cell Line finds diverse applications in scientific research, particularly in the field of respiratory physiology and pathology. Some key applications include:

Disease Modeling

These cells serve as valuable tools for studying various respiratory diseases, such as pulmonary fibrosis, acute respiratory distress syndrome (ARDS), and lung cancer. Researchers can investigate disease mechanisms, screen potential therapeutic agents, and explore novel treatment strategies using this cell line.

Drug Absorption and Toxicity Studies

The cell line provides a relevant in vitro model for assessing the absorption, distribution, metabolism, and excretion (ADME) of inhaled drugs and chemicals. Additionally, researchers can evaluate the toxicity and adverse effects of environmental pollutants, nanoparticles, and pharmaceutical compounds on alveolar epithelial cells.

Barrier Function Studies

As a representative model of the air-blood barrier, these cells enable the investigation of barrier integrity, permeability, and transport mechanisms. Researchers can explore factors influencing epithelial barrier function, such as cytokines, growth factors, and inflammatory mediators, contributing to our understanding of lung physiology and pathology.

Respiratory Infection Research

The cell line facilitates the study of host-pathogen interactions during respiratory infections, including viral, bacterial, and fungal infections. Researchers can investigate the mechanisms of pathogen entry, replication, and immune response activation within alveolar epithelial cells, aiding in the development of antiviral and antibacterial therapies.

Drug Development and Screening

Pharmaceutical companies utilize the cell line in preclinical drug development studies to assess the efficacy and safety of potential therapeutics targeting respiratory disorders. High-throughput screening assays using these cells enable the identification of promising drug candidates for further evaluation in animal models and clinical trials.