For research use only
| Cat No. | ABC-TC0497 |
| Product Type | Mouse Skin Cancer Cell Lines |
| Species | Mouse |
| Growth Conditions | 37 ℃, 5% CO2 |
| Source Organ | Skin |
| Disease | Papilloma |
| Product Code | SP-1; SP1; SENCAR Papilloma 1 |
The KERA-SP1 cell line was etablished from chemical induced papillomas of Sencar mice.
KERA‑SP1 (also known as SP‑1, SP1, SENCAR Papilloma 1) is a mouse keratinocyte cell line derived from chemically induced papillomas of adult SENCAR mouse epidermis, established through a classic two‑stage skin carcinogenesis protocol involving initiation with DMBA and promotion with TPA. The cells exhibit adherent epithelial characteristics typical of papilloma‑derived keratinocytes and carry oncogenic features associated with initiated skin tumor cells from SENCAR mice, including mutations in ras oncogenes as shown in grafting and molecular studies. KERA‑SP1 supports investigation of epidermal cell behavior under tumor‑promoting conditions and in vitro responses to differentiation stimuli such as calcium and vitamin A‑acid, reflecting alterations in keratin expression during tumorigenesis. Metastatic potential is not a defining characteristic of this line. The cells undergo rigorous screening and isolation procedures, and are rigorously tested to ensure they are free of contamination from Mycoplasma, Fungi, Yeast, and Bacteria.
| Product Code | SP-1; SP1; SENCAR Papilloma 1 |
| Species | Mouse |
| Cat.No | ABC-TC0497 |
| Product Category | Tumor Cell Lines |
| Size/Quantity | 1 vial |
| Shipping Info | Dry Ice |
| Growth Conditions | 37 ℃, 5% CO2 |
| Source Organ | Skin |
| Disease | Papilloma |
| Biosafety Level | 1 |
| Storage | Liquid Nitrogen |
| Product Type | Mouse Skin Cancer Cell Lines |
KERA‑SP1 is used as an in vitro model for mouse skin papilloma biology and chemically induced tumorigenesis, supporting studies of keratinocyte proliferation, differentiation, and signal transduction under tumor promotion conditions. It is suitable for investigating epidermal gene and protein expression changes in skin neoplasms, responses to tumor‑promoting agents such as TPA, and comparative analyses of papilloma‑derived versus normal keratinocytes in dermatology and cancer research.
When you publish your research, please cite our product as “AcceGen Biotech Cat.# XXX-0000”. In return, we’ll give you a $200 coupon. Simply click here and submit your paper’s PubMed ID (PMID).
