KLN205/STAT5 Reporter (GFP) Stable Cell Line

Description

KLN205/STAT5 Reporter (GFP) Stable Cell Line is a fluorescent reporter model derived from murine lung squamous carcinoma KLN205 cells, featuring stable integration of a GFP gene under the control of STAT5-responsive promoter elements. This engineered system allows real-time, single-cell monitoring of STAT5 pathway activation through GFP fluorescence, while maintaining the epithelial morphology and tumorigenic properties of parental KLN205 cells. The GFP reporter provides a sensitive tool for visualizing dynamic STAT5 activity in response to cytokines such as IL-2, IL-7, and GM-CSF, or to pharmacological modulators, facilitating research on JAK-STAT signaling and targeted therapy development. Applications include high-content screening of STAT5 modulators, tumor–microenvironment signaling studies, and functional analysis of immune–tumor interactions. Rigorous quality control ensures all cells are free of mycoplasma, fungi, yeast, and bacteria.