KM-H2

The KM-H2 cell line, established from the pleural effusion of a patient with Hodgkin’s disease of mixed cellular type in 1974, represents a vital model for studying human Hodgkin lymphoma. These cells, when cultured, exhibit a predominantly single, spherical morphology in suspension, characterized by a degree of heterogeneity in cell size, including bi- and polynucleated cells. Notably, KM-H2 cells display discernible acid phosphatase and nonspecific esterase activities. They are known for their propensity to form rosettes with T lymphocytes and exhibit positive receptor expression for C3b and the Fc portion of IgG. Furthermore, KM-H2 cells consistently express specific antigens, including Ki-1, Leu-M1, MCS1, HLA-DR, and OKT9. The standard subculturing protocol for KM-H2 cells involves a 1:2 to 1:4 split ratio every second day.

Why choose KM-H2 from AcceGen?

The KM-H2 cell line from AcceGen exhibits exceptional features, including high viability and quality, owing to its incubation under optimal conditions. Furthermore, it has been rigorously screened and found to be negative for mycoplasma and a range of other pathogens, such as EBV, HBV, HCV, HHV-8, HIV-1, HIV-2, HTLV-1/2, MLV, and SMRV, ensuring the integrity and reliability of this cell line for various research applications.