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| Product Code | KMS11; kms11; kms 11 |
| Species | Human |
| Cat.No | ABC-TC0524 |
| Product Category | Tumor Cell Lines |
| Size/Quantity | 1 vial |
| Cell Type | Lymphocyte-like |
| Shipping Info | Dry Ice |
| Growth Conditions | 37 ℃, 5% CO2 |
| Source Organ | Pleural Effusion |
| Biosafety Level | 1 |
| Storage | Liquid Nitrogen |
| Product Type | Human Myeloma Cell Lines |
Human Myeloma Cell Line KMS-11 is derived from pleural effusion of a 67-year-old Japanese female patient with multiple myeloma. These cells are B-cell type and exhibit small round morphology with some multinucleate forms. They secrete immunoglobulin κ (IgG κ) and show positive reaction with PCA-1. KMS-11 has chromosomal abnormalities. The cell line carries a FGFR3 gene mutation (p.Tyr373Cys) and expresses high levels of tumor markers. In terms of tumorigenicity, KMS-11 does not show tumor formation in subcutaneous nude mouse models. They display unique growth properties, including both adherent and suspension growth, making them a valuable model for studying tumor cell heterogeneity and microenvironment adaptation. KMS-11 is widely used in studies on multiple myeloma, immunoglobulin synthesis, and drug screening.
When you publish your research, please cite our product as “AcceGen Biotech Cat.# XXX-0000”. In return, we’ll give you a $100 coupon. Simply click here and submit your paper’s PubMed ID (PMID).
KMS-11 can be used to map proliferation-related signaling pathways in myeloma and identify inhibitors for myeloma cell growth and survival.For example, Interleukin-6 (IL-6) was identified as one of the most important growth factors for myeloma cells, inducing enhanced growth in KMS-11 cells, accompanied by down-regulation of protein kinase C (PKC) activity. JAK inhibitor, which can affect the IL-6/JAK signal transduction, induced cell death of the KMS-11 cells and inhibited tumor growth in a KMS-11 xenograft mouse model. For drug development, ginseng was observed as a candidate for the treatment of myeloma. IH901, a derivative of ginseng,triggered several biochemical events, including the cleavage of poly (ADP-ribose) polymerase (PARP), internucleosomal DNA fragmentation, the activation of caspase-3, the down-regulation of FGFR3, the inhibition of ERK activity, and the apoptosis in KMS-11 cell line.
