For research use only
| Cat No. | ABC-TC0532 |
| Product Type | Human Nerve Tumors Cell Lines |
| Species | Human |
| Growth Conditions | 37 ℃, 5% CO2 |
| Product Code | KNS42 |
KNS-42 glioblastoma cells from a teen male, TP53/BLM-mutated,CD133⁺,GFAP⁺,SOX2⁺,tumorigenic, ideal for stem-like glioma and angiogenesis-related research.
The KNS-42 cell line is a human glioma cell line derived from glioblastoma (primary tumor in the right fronto-parietal lobe of the brain), a malignant glioma, found in a 16-year-old Japanese male patient, histologically confirmed as IDH-wildtype glioblastoma (WHO CNS5 grade 4). In sparse culture, the cells appear polygonal and flat, while in dense culture, they are mainly polygonal with some smaller cells. KNS-42 cells are characterized by their expression of glial markers such as GFAP and S100β, as well as stemness-associated genes including Nestin and CD133. They harbor mutations in the BLM gene (p. Ser186_Lys187delinsTer) and TP53 gene (p. Arg342Ter). KNS-42 cells are tumorigenic and form tumors in immunodeficient mice. KNS-42 cells have been used to model glioma stem-like behavior and response to chemotherapeutics and radiation.
| Product Code | KNS42 |
| Species | Human |
| Cat.No | ABC-TC0532 |
| Product Category | Tumor Cell Lines |
| Size/Quantity | 1 vial |
| Shipping Info | Dry Ice |
| Growth Conditions | 37 ℃, 5% CO2 |
| Biosafety Level | 1 |
| Storage | Liquid Nitrogen |
| Product Type | Human Nerve Tumors Cell Lines |
The KNS-42 cell line has various applications in glioma research. It serves as a valuable tool to evaluate the effectiveness of potential therapies, including radiation, for human glioma treatment. Additionally, KNS-42 cells are utilized to study the migratory characteristics of adult glioma cells and evaluate the impact of small molecule inhibitors targeting migration. Furthermore, this cell line is employed in investigating key oncogenes involved in glioblastoma, focusing on their role in epithelial-mesenchymal transition induction, a critical process in tumor progression.
When you publish your research, please cite our product as “AcceGen Biotech Cat.# XXX-0000”. In return, we’ll give you a $200 coupon. Simply click here and submit your paper’s PubMed ID (PMID).
