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| Species | Human |
| Cat.No | ABC-TC5557 |
| Product Category | Tumor Cell Lines |
| Size/Quantity | 1 vial |
| Shipping Info | Dry ice |
| Growth Conditions | 37 ℃, 5% CO2 |
| Storage | Liquid Nitrogen |
| Product Type | Human Colon Cancer Cell Lines |
LIM1215 is a human colorectal carcinoma cell line derived from a male patient with hereditary nonpolyposis colorectal cancer (HNPCC). This cell line exhibits epithelial-like morphology and adherent growth properties in culture. LIM1215 forms pseudodiploid karyotypes with a modal chromosome number of 46 and contains a 13p+ marker chromosome. Molecular profiling reveals a β-catenin mutation and demonstrates elevated expression of EphA1 receptor, both of which are implicated in colorectal tumorigenesis. The cell line expresses tumor-associated glycoproteins, including cadherin-17 and EpCAM in exosomes. LIM1215 displays tumorigenic potential, forming xenografts in immunocompromised mice, and exhibits metastatic capacity in experimental hepatic models.
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The LIM1215 cell line plays a pivotal role for colorectal cancer research, particularly in the context of hereditary cancer syndromes such as HNPCC. It is prominently utilized to construct LIM1215 xenograft models in immunocompromised mice, facilitating in vivo assessment of tumor progression and therapeutic efficacy. Additionally, LIM1215 cells are instrumental in identifying potential diagnostic and prognostic biomarkers, aiding in early detection and personalized treatment strategies. Moreover, they are employed to EGF-mediated signaling, morphological plasticity, and proliferative mechanisms in colorectal cancer cells. Their exosome profile also makes LIM1215 valuable for studies on tumor-derived extracellular vesicles and intercellular communication in cancer.
