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| Product Code | McA-RH 7777; MCA-RH 7777; McArdle RH-7777; McARH7777; RH7777; Mc Ardle 7777 |
| Species | Rattus Norvegicus |
| Cat.No | ABC-TC0636 |
| Product Category | Tumor Cell Lines |
| Size/Quantity | 1 vial |
| Cell Type | Hepatocyte |
| Shipping Info | Dry Ice |
| Growth Conditions | 37 ℃, 5% CO2 |
| Source Organ | Liver |
| Disease | Hepatoma |
| Biosafety Level | 1 |
| Storage | Liquid Nitrogen |
| Product Type | Rat Liver Cancer Cell Lines |
The MCA-RH 7777 cell line is an epithelial-like cell line derived from the liver of a rat with Morris hepatoma 7777. These cells display adherent growth with a distinctive fusiform and polygonal appearance.
Upon subcutaneous injection, they induce subcutaneous tumors in rats. In vitro, the McA-RH 7777 cells are dynamically engaged in the production and release of plasma lipoproteins. Notably, MCA-RH 7777 cells produce α-fetoprotein (AFP) and exhibit elevated levels of L-histidine decarboxylase (HDC) expression, leading to histamine (HA) synthesis. Expressing both H3-receptor (H3R) transcripts and proteins, these cells’ proliferation is modulated by HA via interactions with autoinhibitory H3Rs. Subculture involves a 1:2 to 1:6 split of semi-confluent cultures.
Why choose MCA-RH 7777 from AcceGen?
MCA-RH 7777 from AcceGen is preferred for its exceptional viability and quality, maintained through stringent quality control measures. The cell line is delivered sterile, accompanied by optimal incubation guidelines, and benefits from an advanced cryopreservation technique, ensuring its reliability for a range of research applications.
When you publish your research, please cite our product as “AcceGen Biotech Cat.# XXX-0000”. In return, we’ll give you a $100 coupon. Simply click here and submit your paper’s PubMed ID (PMID).
FOR RESEARCH USE ONLY
The versatile MCA-RH 7777 cell line serves a multitude of purposes in scientific exploration. It plays a pivotal role in researching liver cancer metastasis, recurrence patterns, and innovative interventional therapies, while also contributing significantly to drug screening initiatives. Beyond this, the cell line is instrumental in tumorigenicity and oncogeny studies, shedding light on crucial aspects of cancer development. Additionally, it offers a valuable platform for investigating the intricate mechanisms governing the biogenesis of plasma lipoproteins.
