For research use only
| Cat No. | ABL-TC0396 |
| Product Type | Human Ovarian Cancer Cell Lines |
| Species | Human |
| Growth Conditions | 37 ℃, 5% CO2 |
| Source Organ | Ovary |
Discover the MCAS cell line:a tumorigenic, adherent human epithelial ovarian cancer model.Features hypertetraploidy and a distinct,large-fused morphology.
MCAS is a human epithelial ovarian mucinous cystadenocarcinoma cell line derived from primary ovarian tissue. The cells grow adherently and display large, fused morphology with prominent cytoplasmic vacuoles, and PAS staining is positive in these enlarged cells. Cytogenetic analysis shows a tendency toward hypertetraploidy. Genomic profiling reveals key oncogenic mutations including homozygous CDKN2A p.Arg80Ter, KRAS p.Gly12Asp, PIK3CA p.His1047Arg, and SMAD4 p.Ser504Arg, characteristic of ovarian mucinous carcinoma. MCAS cells are tumorigenic in immunodeficient mice, forming xenografts that replicate histological features of the original tumor, and they demonstrate metastatic potential in suitable in vivo models.
| Species | Human |
| Cat.No | ABL-TC0396 |
| Product Category | Tumor Cell Lines |
| Size/Quantity | 1 vial |
| Shipping Info | Dry Ice |
| Growth Conditions | 37 ℃, 5% CO2 |
| Source Organ | Ovary |
| Biosafety Level | 1 |
| Storage | Liquid Nitrogen |
| Product Type | Human Ovarian Cancer Cell Lines |
The MCAS cell line is an important tool in mucinous ovarian carcinoma research. It is used to screen potential drugs and investigate mechanisms that inhibit tumor cell growth. Researchers rely on this line to study molecular pathways involved in ovarian cancer and to identify promising therapeutic strategies. Its applications contribute significantly to the advancement of ovarian cancer treatment.
When you publish your research, please cite our product as “AcceGen Biotech Cat.# XXX-0000”. In return, we’ll give you a $200 coupon. Simply click here and submit your paper’s PubMed ID (PMID).
