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| Species | Mouse |
| Cat.No | ABC-TC3928 |
| Quality Control | All cells test negative for mycoplasma, bacteria, yeast, and fungi. |
| Product Category | Primary Cells |
| Size/Quantity | 1 vial |
| Cell Type | Hepatocyte |
| Shipping Info | Dry Ice |
| Growth Conditions | 37 ℃, 5% CO2 |
| Source Organ | Liver |
| Disease | Normal |
| Biosafety Level | 1 |
| Storage | Liquid Nitrogen |
| Product Type | Mouse Primary Cells |
Mouse hepatocytes are primary liver cells isolated from murine liver tissue. These hepatocytes exhibit polygonal morphology, form tight monolayers in adherent culture, and display typical cellular polarity, including distinct apical and basolateral domains. Functionally, mouse hepatocytes perform key hepatic roles such as albumin production, urea synthesis, bile canaliculi formation, and cytochrome P450 enzyme activity. These cells also express liver-specific transporters and receptors, allowing investigation of xenobiotic metabolism, drug-induced liver injury, and lipid/glucose metabolism. Karyotypic analysis confirms a normal diploid murine genome, and they are confirmed to express high levels of albumin, CYP enzymes, and transport proteins such as Oatp1 and Mrp2. These cells are non-transformed, with limited passage capacity, and typically used at passage 0 or 1 to preserve native hepatic functionality.
When you publish your research, please cite our product as “AcceGen Biotech Cat.# XXX-0000”. In return, we’ll give you a $100 coupon. Simply click here and submit your paper’s PubMed ID (PMID).
Dong, J., Adami, E., Chothani, S.P., Viswanathan, S., Ng, B., Lim, W.W., Singh, B.K., Zhou, J., Ko, N.S., Shekeran, S.G. and Tan, J., 2020. Autocrine IL11 cis-signaling in hepatocytes is an initiating nexus between lipotoxicity and non-alcoholic steatohepatitis. bioRxiv.
Dong, J., Viswanathan, S., Adami, E., Singh, B.K., Chothani, S.P., Ng, B., Lim, W.W., Zhou, J., Tripathi, M., Ko, N.S. and Shekeran, S.G., 2021. Hepatocyte-specific IL11 cis-signaling drives lipotoxicity and underlies the transition from NAFLD to NASH. Nature Communications, 12(1), pp.1-15.
Viswanathan, S., Ng, B., Widjaja, A.A., Pua, C.J., Tham, N., Tan, J., Cook, S.A. and Schafer, S., 2021. Critical Conditions for Studying Interleukin‐11 Signaling In Vitro and Avoiding Experimental Artefacts. Current protocols, 1(9), p.e251.
Mouse hepatocytes are integral to a wide range of preclinical and basic research applications. They provide a cost-effective and accessible model for studying liver-specific functions. Their relevance is particularly significant in drug development and toxicology studies, where they are used to assess hepatotoxicity, drug metabolism, and safety profiles. As primary hepatocytes, they serve as a robust ex vivo alternative, supporting translational research in liver biology, disease modeling, and pharmacokinetics.
