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| Product Code | OSCA-8; OSCA8; OSA8 |
| Species | Canine |
| Cat.No | ABC-TC5571 |
| Product Category | Tumor Cell Lines |
| Size/Quantity | 1 vial |
| Shipping Info | Dry ice |
| Growth Conditions | 37 ℃, 5% CO2 |
| Storage | Liquid Nitrogen |
| Product Type | Canine Sarcoma Cell Lines |
OSCA-8 is a canine osteosarcoma cell line that was originally isolated from the humerus of a 2-year-old male Rottweiler with osteosarcoma. OSCA-8 exhibits spindle-shaped morphology and adherent culture properties. This cell line is tumorigenic; it gives rise to both orthotopic and heterotopic tumor xenografts in SCID mice. The genomic profile of OSCA-8 resembles the most aggressive type of osteosarcoma. Osteosarcoma arises from primitive transformed cells of mesenchymal origin, which demonstrate osteoblastic differentiation and generate malignant osteoid.
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The OSCA-8 cell line’s relevance lies in its application to address the challenges of canine osteosarcoma, characterized by high metastasis rates and a grim prognosis. It serves as a valuable tool to examine inhibitor cytotoxicity, elucidate resistance mechanisms against established drugs, and innovate novel therapeutic approaches to induce apoptosis. OSCA-8 contributes significantly to advancing the understanding and management of this aggressive disease in canines.
