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Tumor Cell Lines

OVSAHO

  • BSL

    1

  • 308
Ovarian adenocarcinoma. Cells are transplantable to both mouse hypodermis and abdominal.
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Home | Tumor Cell Lines | Human Tumor Cell Lines | OVSAHO
Species

Human
Cat.No

ABC-TC0886
Product Category Tumor Cell Lines
Size/Quantity

1 vial
Shipping Info

Dry Ice
Growth Conditions

37 ℃, 5% CO2
Biosafety Level

1
Storage

Liquid Nitrogen
Product Type

Human Ovarian Cancer Cell Lines

Description

OVSAHO is a permanent epithelial ovarian carcinoma cell line derived from the abdominal metastatic tumor of a 56-year-old Japanese female with high-grade serous adenocarcinoma. The original tissue was a solid tumor from the ovary, making OVSAHO a widely used model in ovarian cancer research. These cells grow adherently in monolayer culture and display epithelial morphology with a moderately polygonal shape. OVSAHO cells express a variety of cytokeratins including CK6, CK7, CK8, CK14, CK15/16, CK18, and CK19. Cytogenetic analysis reveals a complex karyotype, and they harbor a TP53 nonsense mutation (c.1024C>T; p.Arg342Ter), while retaining wild-type BRCA1. The cells are tumorigenic in both immunodeficient and immunocompetent mice, forming tumors via subcutaneous, intraperitoneal, and orthotopic injection, but show no evidence of metastasis. They are HPV- and EBV-negative. This cell line offers a reliable preclinical platform for investigating serous ovarian carcinoma and p53-related pathways.
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Application

  • The OVSAHO cell line is widely used in ovarian cancer research. As one of the frequently employed tumor models, it important for in vitro screening of experimental anticancer agents. Researchers can rely on OVSAHO to explore specific histologic subtypes and the response to various agents. Additionally, OVSAHO’s utility extends to xenograft models, where supports xenograft-based preclinical drug testing, contributing to the advancement of ovarian cancer treatment strategies.

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