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PC-3

Product Name

PC-3

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Product Code

PC3; PC.3

Cat.No

ABC-TC0903

Species

Human

Size/Quantity

1 vial

Biosafety Level

1

Shipping Info

Dry Ice

Storage

Liquid Nitrogen

Description

PC-3 is a cell line derived from a bone metastasis of a grade IV prostatic adenocarcinoma in a 62-year-old White male, known for its high metastatic potential. Notably, PC-3 cells are androgen-independent, unresponsive to androgens, glucocorticoids, or fibroblast growth factors, and instead, they are influenced by epidermal growth factors. Unlike other prostate cancer cell models, they exhibit low testosterone-5-alpha reductase and acidic phosphatase activity and do not express prostate-specific antigen (PSA). PC-3 cells are characterized by their small-cell neoendocrine carcinoma phenotype and exhibit distinctive morphological and molecular features. In terms of size, PC-3 cells measure approximately 15.1 to 16.6 micrometers in diameter.

 

Why choose PC-3 from AcceGen?

PC-3 cells exhibit high viability and quality, ensuring robust experimental outcomes. They are maintained under sterile conditions, rigorously tested to be negative for bacteria, fungi, and mycoplasma contamination, and their identity is confirmed through STR analysis, emphasizing their reliability and adherence to stringent quality control standards.

Source Organ

Prostate

Recommended Medium And Supplement
Citation Guide

When you publish your research, please cite our product as “AcceGen Biotech Cat.# XXX-0000”. In return, we’ll give you a $100 coupon. Simply click here and submit your paper’s PubMed ID (PMID).
Saranyutanon, S., Deshmukh, S.K., Dasgupta, S., Pai, S., Singh, S. and Singh, A.P., 2020. Cellular and Molecular Progression of Prostate Cancer: Models for Basic and Preclinical Research. Cancers, 12(9), p.2651.

Application

FOR RESEARCH USE ONLY

The PC-3 cell line is a crucial asset in prostate cancer research, allowing scientists to delve into biochemical alterations and assess how advanced prostate cancer cells respond to various chemotherapeutic agents. Beyond this, PC-3 cells are commonly employed in studies focusing on viral infections within mammalian cells that display an immune response. Their versatility extends to serving as a suitable host for transfection experiments, making PC-3 cells a versatile tool for researchers across diverse fields. They are particularly valuable for investigating the intricacies of the tumor environment and evaluating the efficacy of therapeutic drugs.

Growth Conditions

37 ℃, 5% CO2

Cell Type

Epithelial

Growth Mode

Adherent

Product Type

Human Prostate Cancer Cell Lines

Product Image AcceGen Frozen Cells & Cell Lines 1 vial
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