For research use only
| Cat No. | ABC-TC1272 |
| Product Type | Human Prostate Cancer Cell Lines |
| Cell Type | Epithelial |
| Species | Human |
| Growth Conditions | 37 ℃, 5% CO2 |
| Source Organ | Prostate |
| Disease | Prostate Cancer |
| Product Code | VCAP; Vcap; Vertebral Cancer of the Prostate |
VCaP prostate cancer cells express PSA, PAP, androgen receptor; tumorigenic with chromothripsis on chromosome 5; robust hormone-sensitive model.
VCaP is a human prostate adenocarcinoma cell line that was originally isolated from the metastatic lesion in the lumbar vertebrae of a 59-year-old Caucasian male patient with hormone-refractory prostate cancer in 1997. These cells grow as adherent epithelial cells, often forming floating clusters and monolayer clumps, and requires careful handling and conditioned medium due to its fragile nature. VCaP expresses high levels of androgen receptor (AR), including the AR‑V7 splice variant, along with prostate‑specific antigen (PSA), prostatic acid phosphatase (PAP), and cytokeratin‑18. It harbors the TMPRSS2‑ERG gene fusion and displays chromothripsis‑type rearrangements on chromosome 5q. VCaP is immortal in vitro and tumorigenic in immunodeficient mice, forming tumors in both nude and SCID models. The line exhibits robust androgen sensitivity and also supports androgen‑independent growth when adapted.
| Product Code | VCAP; Vcap; Vertebral Cancer of the Prostate |
| Species | Human |
| Cat.No | ABC-TC1272 |
| Product Category | Tumor Cell Lines |
| Size/Quantity | 1 vial |
| Cell Type | Epithelial |
| Growth Mode | Adherent |
| Shipping Info | Dry Ice |
| Growth Conditions | 37 ℃, 5% CO2 |
| Source Organ | Prostate |
| Disease | Prostate Cancer |
| Biosafety Level | 1 |
| Storage | Liquid Nitrogen |
| Product Type | Human Prostate Cancer Cell Lines |
The VCaP cell line serves as a valuable cell-based model for human prostate cancer, enhancing the toolkit for studying the mechanisms driving prostate cancer progression and metastasis. Its application extends to investigating crucial factors like the human retrovirus XMRV (xenotropic murine leukemia virus-related virus) within prostate carcinoma. The cells are tumourigenic in SCID mice. With its expression of unaltered androgen receptor and ability to proliferate independently of androgens, the VCaP cell line is exceptionally suited for investigating the intricate dynamics of castration-resistant prostate cancer.
When you publish your research, please cite our product as “AcceGen Biotech Cat.# XXX-0000”. In return, we’ll give you a $200 coupon. Simply click here and submit your paper’s PubMed ID (PMID).
Saranyutanon S, Deshmukh SK, Dasgupta S, Pai S, Singh S, Singh AP. Cellular and Molecular Progression of Prostate Cancer: Models for Basic and Preclinical Research. Cancers (Basel). 2020;12(9):2651. Published 2020 Sep 17. doi:10.3390/cancers12092651
