Rabbit Intestinal Microvascular Endothelial Cells are primary cells isolated from the intestinal tissue of White Rabbits. They form a monolayer lining the microvessels, serving as a barrier for nutrient, gas, and waste exchange. Morphologically, they display a polygonal, epithelial-like appearance and adhere as a monolayer. Cultured from normal tissue, they exhibit typical endothelial behavior. Functionally, these cells participate in intestinal barrier regulation, nutrient transport and immune cell recruitment (through the expression of VCAM-1/ICAM-1 and the secretion of IL-6/IL-8). Their unique fenestrations and low levels of tight junction proteins distinguish them from large vascular endothelial cells and adapt to the high permeability requirements of the intestine. In addition, RIMECs highly express CD31/PECAM-1 and vWF factors and have the ability to take up acetylated LDL (DiI-Ac-LDL experiment). 
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