Rabbit Intestinal Microvascular Endothelial Cells

Description

Rabbit Intestinal Microvascular Endothelial Cells are primary cells isolated from the intestinal tissue of White Rabbits. They form a monolayer lining the microvessels, serving as a barrier for nutrient, gas, and waste exchange. Morphologically, they display a polygonal, epithelial-like appearance and adhere as a monolayer. Cultured from normal tissue, they exhibit typical endothelial behavior. Functionally, these cells participate in intestinal barrier regulation, nutrient transport and immune cell recruitment (through the expression of VCAM-1/ICAM-1 and the secretion of IL-6/IL-8). Their unique fenestrations and low levels of tight junction proteins distinguish them from large vascular endothelial cells and adapt to the high permeability requirements of the intestine. In addition, RIMECs highly express CD31/PECAM-1 and vWF factors and have the ability to take up acetylated LDL (DiI-Ac-LDL experiment).

Application

• The applications of rabbit intestinal microvascular endothelial cells provide insights into disease mechanisms, identifying therapeutic targets, and developing novel treatments. By studying these cells, researchers gain a better understanding of the underlying mechanisms of gastrointestinal diseases, supporting the discovery of therapeutic targets. Additionally,studying their function advances understanding on maintaining intestinal health and addressing related disorders. This knowledge can lead to individualized interventions and precision therapies, improving outcomes for gastrointestinal conditions.