Rat Neonatal Dorsal Root Ganglion (DRG) Neurons are primary sensory neurons isolated from the spinal cord tissue of neonatal rats. Originating from the neural crest, these neurons form clusters along the spinal nerve roots and are essential mediators of sensory signal transduction between peripheral receptors and the central nervous system. In culture, DRG neurons exhibit irregular morphology, grow adherently, and extend axons into dense, interconnected networks. DRG neurons express key functional markers such as voltage-gated sodium channels and neurotrophin receptors (e.g., TrkA), enabling nociceptive transmission, axon guidance, and synaptic plasticity. These primary neurons are non-proliferative, therefore cannot be passaged repeatedly and require specialized media to maintain viability.
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