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Tumor Cell Lines

RD

  • BSL

    1

  • 211
Tissue: muscle Disease: rhabdomyosarcoma.
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Product Code

R D; RD-2; RD 2; 130T; 130-T; 130 T; TE-32; TE 32; TE32; TE 32.T; Te 32.T

Species

Human

Cat.No

ABC-TC0954

Product Category Tumor Cell Lines
Size/Quantity

1 vial

Shipping Info

Dry Ice

Growth Conditions

37 ℃, 5% CO2

Source Organ

Muscle

Biosafety Level

1

Storage

Liquid Nitrogen

Product Type

Human Myoma Cell Lines

Description

RD is a human Embryonal rhabdomyosarcoma (ERMS) cell line that was originally isolated from biopsy specimens of a 7-year-old female with a pelvic RMS previously treated with cyclophosphamide and radiation and found to have refractory disease. RD exhibits fibroblast-like morphology and adherent culture properties. Rhabdomyosarcoma (RD) displays embryonal histology and a 51-hyperdiploid chromosome karyotype. RD has been shown to harbor MYC oncogene amplification, an NRAS Q61H mutation, and a homozygous TP53 mutation.
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Citation

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Application

  • The RD cell line is a classical model for studying rhabdomyosarcoma, a pediatric soft tissue cancer. It has been used to evaluate chemotherapy agents like vincristine and cyclophosphamide and investigate molecular events involved in tumor progression and metastasis. RD cells are also valuable in multistage carcinogenesis studies and drug screening, particularly for exploring anti-cancer compounds and their effects on tumor growth and gene expression.

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