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Transfected Stable Cell Lines

RPMI-8226/STAT5 Reporter (GFP) Stable Cell Line

  • For research use only

Cat No.

ABC-RC032Y
Product Type

Reporter Stable Cell Lines
Cell Type

B Lymphocyte
Species

Human
Host Cell

RPMI-8226
Source Organ

Peripheral Blood
Disease

Myeloma
Storage

Liquid Nitrogen

RPMI-8226/STAT5 Reporter (GFP) Stable Cell Line by AcceGen is for real-time visualization of STAT5 signaling dynamics in multiple myeloma progression.

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  • RPMI-8226/STAT5 Reporter (GFP) Stable Cell Line
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Home | Transfected Stable Cell Lines | RPMI-8226/STAT5 Reporter (GFP) Stable Cell Line

Description

RPMI-8226/STAT5 Reporter (GFP) Stable Cell Line is a genetically engineered human multiple myeloma model featuring a STAT5 (Signal Transducer and Activator of Transcription 5)-responsive GFP reporter system in RPMI-8226 cells. This specialized cell line maintains characteristic plasma cell morphology and retains native multiple myeloma markers (CD38, CD138) while enabling sensitive monitoring of JAK-STAT signaling pathway activation through GFP fluorescence intensity. The STAT5-responsive reporter allows real-time tracking of STAT5 transcriptional activity, making it particularly valuable for studying cytokine signaling, drug mechanisms, and resistance development in hematological malignancies. GFP expression levels directly correlate with STAT5 pathway activation, providing a visual and quantitative readout for high-content screening applications. Cryopreserved at low passage (<P20) to ensure reporter stability, genetic integrity, and consistent performance. The cells are rigorously tested to ensure they are free of contamination from HIV-1, HBV, HCV, Syphilis, Mycoplasma, Fungi, Yeast and Bacteria.

Species

Human
Cat.No

ABC-RC032Y
Product Category

Transfected Stable Cell Lines
Size/Quantity

1 vial
Cell Type

B Lymphocyte
Growth Mode

Suspension
Shipping Info

Dry Ice
Growth Conditions

37 ℃, 5% CO2
Source Organ

Peripheral Blood
Disease

Myeloma
Biosafety Level

2
Storage

Liquid Nitrogen
Product Type

Reporter Stable Cell Lines
Host Cell

RPMI-8226
Gene Info

STAT5 / GFP
Quality Control

All cells test negative for mycoplasma, bacteria, yeast, and fungi.

Application

  • The RPMI-8226/STAT5 Reporter (GFP) Stable Cell Line is engineered to monitor STAT5 signaling activity in multiple myeloma research. This reporter system links STAT5 transcriptional activation to GFP expression, enabling real-time visualization of pathway dynamics via fluorescence detection. Particularly valuable for studying JAK-STAT signaling, drug mechanisms, and cytokine responses, the cell line provides quantitative readouts of STAT5 activity under various treatments. Maintain in RPMI-1640 medium with appropriate selection agents to ensure reporter stability. Ideal for high-content screening and functional genomics applications in hematologic malignancies.

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