RPMI-8226/STAT5 Reporter (Luc) Stable Cell Line

Description

RPMI-8226/STAT5 Reporter (Luc) Stable Cell Line is a genetically engineered human multiple myeloma model featuring a STAT5-responsive luciferase reporter system in RPMI-8226 cells. This specialized cell line maintains characteristic plasma cell morphology and retains native multiple myeloma markers (CD38, CD138) while enabling highly sensitive, quantitative monitoring of STAT5 signaling pathway activation through bioluminescence detection. The luciferase reporter provides a robust quantitative readout of STAT5 transcriptional activity, making it particularly valuable for studying JAK-STAT signaling in hematologic malignancies, screening STAT5-targeting therapeutics, and investigating drug resistance mechanisms. The non-destructive luciferase assay allows longitudinal tracking of STAT5 activation dynamics in both in vitro and in vivo applications. Cryopreserved at low passage (<P20) to ensure genetic stability and consistent reporter performance. The cells are rigorously tested to ensure they are free of contamination from HIV-1, HBV, HCV, Syphilis, Mycoplasma, Fungi, Yeast and Bacteria.