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Tumor Cell Lines

SKN-3

  • BSL

    1

  • 252
Established through xenotransplaned tumor in nude mice. Squamous carcinoma.
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Product Code

SKN3

Species

Human

Cat.No

ABC-TC1043

Product Category Tumor Cell Lines
Size/Quantity

1 vial

Cell Type

Epithelial-like

Shipping Info

Dry Ice

Growth Conditions

37 ℃, 5% CO2

Biosafety Level

1

Storage

Liquid Nitrogen

Product Type

Human Oral Cancer Cell Lines

Description

SKN-3SKN-3 is a human oral squamous cell carcinoma (OSCC) cell line established via xenotransplantation in mice, derived from a patient with OSCC. This cell line exhibits epithelial-like morphology and adherent growth properties in culture. Genomic profiling identifies a recurrent 2.5-Mb amplification at 19q13.12-13.2, forming homogeneously staining regions and containing 66 transcripts, including the oncogene PAK4, which is markedly overexpressed and drives proliferation through kinase-dependent pathways. SKN-3 demonstrates tumorigenic and metastatic potential in preclinical models, mirroring the aggressive behavior of OSCC .

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Citation

When you publish your research, please cite our product as “AcceGen Biotech Cat.# XXX-0000”. In return, we’ll give you a $100 coupon. Simply click here and submit your paper’s PubMed ID (PMID).

Peng, M., & Pang, C. (2019). MicroRNA‐140‐5p inhibits the tumorigenesis of oral squamous cell carcinoma by targeting p21‐activated kinase 4. Cell Biology International, 44(1), 145-154. https://doi.org/10.1002/cbin.11213

Application

  • The SKN-3 cell line serves as a valuable tool in various applications related to oral squamous cell carcinoma (OSCC). It is utilized to study the development and progression of OSCC, providing insights into the tumorigenic mechanisms underlying head and neck cancers. Additionally, researchers use SKN-3 cells to investigate genetic and epigenetic mechanisms that may play pivotal roles in oral tumorigenesis. Moreover, the cell line helps examine the functions of key factors in signaling pathways that promote cancers, making it a promising target for potential therapies against multiple cancer types.

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High Viability
To succeed in cell culture
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To support a consistent result
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