For research use only
| Cat No. | ABC-TC1043 |
| Product Type | Human Oral Cancer Cell Lines |
| Cell Type | Epithelial-like |
| Species | Human |
| Growth Conditions | 37 ℃, 5% CO2 |
| Product Code | SKN3 |
SKN-3 OSCC cells have epithelial morphology, PAK4 oncogene amplification, and high tumorigenic and metastatic potential in preclinical models.
SKN-3 is a human oral squamous cell carcinoma (OSCC) cell line originally derived from a patient tumor and established via xenotransplantation in immunodeficient mice. These cells are of epithelial origin and display polygonal morphology with strong adherent growth in monolayer culture. Cytogenetic analysis reveals a 2. 5-Mb amplification at chromosome region 19q13. 12–13. 2, forming homogeneously staining regions and encompassing 66 genes. Among these, the oncogene PAK4 is highly overexpressed, promoting cell proliferation and survival via kinase-dependent signaling cascades. SKN-3 cells exhibit strong tumorigenic and metastatic capacity in nude mouse models, making them an excellent in vivo model for aggressive OSCC. Gene expression profiles also indicate upregulation of cell cycle and invasion-associated markers. This cell line recapitulates key pathological features of advanced oral cancer, supporting its utility in therapeutic development and cancer progression research.
| Product Code | SKN3 |
| Species | Human |
| Cat.No | ABC-TC1043 |
| Product Category | Tumor Cell Lines |
| Size/Quantity | 1 vial |
| Cell Type | Epithelial-like |
| Shipping Info | Dry Ice |
| Growth Conditions | 37 ℃, 5% CO2 |
| Biosafety Level | 1 |
| Storage | Liquid Nitrogen |
| Product Type | Human Oral Cancer Cell Lines |
The SKN-3 cell line is a valuable model for oral squamous cell carcinoma (OSCC) research, enabling studies on tumor development and progression in head and neck cancers. It is extensively used to investigate the genetic and epigenetic mechanisms driving oral tumorigenesis. Additionally, SKN-3 cells facilitate exploration of critical signaling pathways involved in cancer promotion, identifying potential therapeutic targets for OSCC and other related cancers.
When you publish your research, please cite our product as “AcceGen Biotech Cat.# XXX-0000”. In return, we’ll give you a $200 coupon. Simply click here and submit your paper’s PubMed ID (PMID).
Peng M, Pang C. MicroRNA-140-5p inhibits the tumorigenesis of oral squamous cell carcinoma by targeting p21-activated kinase 4. Cell Biol Int. 2020;44(1):145-154. doi:10.1002/cbin.11213
