For research use only
| Cat No. | ABC-TC1043 |
| Product Type | Human Oral Cancer Cell Lines |
| Cell Type | Epithelial-like |
| Species | Human |
| Growth Conditions | 37 ℃, 5% CO2 |
| Product Code | SKN3 |
SKN-3 OSCC cells have epithelial morphology, PAK4 oncogene amplification, and high tumorigenic and metastatic potential in preclinical models.
SKN-3 is a human oral squamous cell carcinoma (OSCC) cell line established via xenotransplantation in mice, derived from a patient with OSCC. This cell line exhibits epithelial-like morphology and adherent growth properties in culture. Genomic profiling identifies a recurrent 2.5-Mb amplification at 19q13.12-13.2, forming homogeneously staining regions and containing 66 transcripts, including the oncogene PAK4, which is markedly overexpressed and drives proliferation through kinase-dependent pathways. SKN-3 demonstrates tumorigenic and metastatic potential in preclinical models, mirroring the aggressive behavior of OSCC .
| Product Code | SKN3 |
| Species | Human |
| Cat.No | ABC-TC1043 |
| Product Category | Tumor Cell Lines |
| Size/Quantity | 1 vial |
| Cell Type | Epithelial-like |
| Shipping Info | Dry Ice |
| Growth Conditions | 37 ℃, 5% CO2 |
| Biosafety Level | 1 |
| Storage | Liquid Nitrogen |
| Product Type | Human Oral Cancer Cell Lines |
The SKN-3 cell line serves as a valuable tool in various applications related to oral squamous cell carcinoma (OSCC). It is utilized to study the development and progression of OSCC, providing insights into the tumorigenic mechanisms underlying head and neck cancers. Additionally, researchers use SKN-3 cells to investigate genetic and epigenetic mechanisms that may play pivotal roles in oral tumorigenesis. Moreover, the cell line helps examine the functions of key factors in signaling pathways that promote cancers, making it a promising target for potential therapies against multiple cancer types.
When you publish your research, please cite our product as “AcceGen Biotech Cat.# XXX-0000”. In return, we’ll give you a $100 coupon. Simply click here and submit your paper’s PubMed ID (PMID).
Peng M, Pang C. MicroRNA-140-5p inhibits the tumorigenesis of oral squamous cell carcinoma by targeting p21-activated kinase 4. Cell Biol Int. 2020;44(1):145-154. doi:10.1002/cbin.11213
