For research use only
| Cat No. | ABC-TC1224 |
| Product Type | Mouse Kidney Cell Lines |
| Cell Type | Epithelial |
| Species | Mouse-Weanling, Mus Musculus |
| Growth Conditions | 37 ℃, 5% CO2 |
| Source Organ | Kidney |
| Disease | Normal |
| Product Code | TCMK1; Transformed C3H Mouse Kidney-1 |
TCMK-1 cells transformed by SV40 serve as kidney models, SV40 T-antigen positive, tumorigenicity negative, supporting renal biology research.
TCMK-1 is a SV40‑transformed mouse renal tubular epithelial cell line derived from the kidney of a juvenile C3H/Mai mouse. These cells exhibit polygonal epithelial morphology and grow as adherent monolayer. TCMK-1 cells express a positive SV40 T-antigen. The line exhibits an aneuploid modal chromosome number of around 78 (range 64–157), with 2–6 acrocentric chromosomes bearing secondary constrictions and 1–4 bi-armed chromosomes per cell. While non-tumorigenic in vivo, TCMK‑1 demonstrates anchorage-independent growth in semisolid medium. Designed with a normal histopathology profile and epithelial origin, this cell line serves as a reliable model of mouse kidney epithelial transformation for studies in viral oncogeny, karyotype instability, and epithelial cell physiology under virus-mediated immortalization.
| Product Code | TCMK1; Transformed C3H Mouse Kidney-1 |
| Species | Mouse-Weanling, Mus Musculus |
| Cat.No | ABC-TC1224 |
| Product Category | Tumor Cell Lines |
| Size/Quantity | 1 vial |
| Cell Type | Epithelial |
| Growth Mode | Adherent |
| Shipping Info | Dry Ice |
| Growth Conditions | 37 ℃, 5% CO2 |
| Source Organ | Kidney |
| Disease | Normal |
| Biosafety Level | 1 |
| Storage | Liquid Nitrogen |
| Product Type | Mouse Kidney Cell Lines |
The TCMK-1 cell line is a valuable model for studying renal pathophysiology, particularly in the context of renal tubular injury. It is widely used to investigate mechanisms of mitochondrial dysfunction, hypoxia/reoxygenation injury, and sepsis-induced acute kidney injury (AKI). They are indtrumental in drug development endeavors aimed at preventing or ameliorating injury and inhibiting renal tubular cell apoptosis. Moreover, TCMK-1 cells play a crucial role in elucidating related regulation pathways involved in renal injury and repair, offering critical insights for the development of novel treatments for AKI and other kidney-related disorders.
When you publish your research, please cite our product as “AcceGen Biotech Cat.# XXX-0000”. In return, we’ll give you a $200 coupon. Simply click here and submit your paper’s PubMed ID (PMID).
