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| Product Code | THLE3; Transformed Human Liver Epithelial-3 |
| Species | Human |
| Cat.No | ABC-TC1338 |
| Product Category | Tumor Cell Lines |
| Size/Quantity | 1 vial |
| Cell Type | Epithelial |
| Shipping Info | Dry Ice |
| Growth Conditions | 37 ℃, 5% CO2 |
| Source Organ | Liver |
| Disease | Normal |
| Biosafety Level | 2 |
| Storage | Liquid Nitrogen |
| Product Type | Human Liver Cell Lines |
THLE-3 is a human liver epithelial cell line derived from the left lobe of a healthy adult liver donor. The cells were immortalized using SV40 large T antigen, a viral oncoprotein commonly used to extend the proliferative capacity of primary cells. THLE-3 exhibits features similar to normal adult liver epithelial cells and lacks expression of alpha-fetoprotein. These cells are non-tumorigenic and non-metastatic in athymic nude mice, with a near-diploid karyotype. Functionally, they retain active cytochrome P450 enzymatic pathways and are capable of metabolizing benzo[a]pyrene, N-nitrosodimethylamine, and aflatoxin B1 into DNA-adducting carcinogenic intermediates. THLE-3 cells do not carry any known specific gene mutations or oncogene overexpression, aside from transformation by SV40 large T antigen. It serves as a reliable model for liver toxicology, drug metabolism, and xenobiotic biotransformation studies.
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THLE-3 cells are used in pharmacotoxicological research and hepatocellular carcinoma pathogenesis studies. As immortalized human liver cells, they offer a reliable in vitro model for liver toxicity and cancer research. Their application lies in being a normal cell model for various assays, enabling comparison of responses to compounds between healthy and cancerous liver cells, ensuring that potential effects of substances are specifically targeted towards diseased cells while leaving healthy cells unaffected.
