| Species |
Human
|
| Cat.No |
ABC-RC048Y
|
| Quality Control |
All cells test negative for mycoplasma, bacteria, yeast, and fungi.
|
| Product Category |
Transfected Stable Cell Lines |
| Size/Quantity |
1 vial
|
| Cell Type |
Monocyte
|
| Shipping Info |
Dry Ice
|
| Growth Conditions |
37 ℃, 5% CO2
|
| Source Organ |
Peripheral Blood
|
| Disease |
Acute Monocytic Leukemia
|
| Biosafety Level |
1
|
| Storage |
Liquid Nitrogen
|
| Product Type |
Reporter Stable Cell Lines
|
| Host Cell |
THP-1
|
| Gene Info |
STAT5 / GFP
|
Description
THP-1/STAT5 Reporter (GFP) Stable Cell Line is a genetically modified human monocytic cell line designed to monitor STAT5 (Signal Transducer and Activator of Transcription 5) signaling pathway activation through green fluorescent protein (GFP) expression. Derived from the THP-1 parental cell line, the cell line maintains key native THP-1 characteristics, such as the capacity to upregulate CD14 upon differentiation and PMA-induced differentiation into macrophage-like cells. The cell line features a GFP reporter gene under the control of STAT5-responsive elements, enabling real-time visualization and quantitative analysis of STAT5 activation in response to cytokine stimulation (including IL-2, IL-7, and GM-CSF). With stable GFP expression maintained at low passage numbers (<P20), this cell line serves as a valuable tool for studying immune cell signaling, hematopoiesis, and potential therapeutic interventions. The cells are rigorously tested to ensure they are free of contamination from HIV-1, HBV, HCV, Syphilis, mycoplasma, Fungi, Yeast and Bacteria.
