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Transfected Stable Cell Lines

TNFRSF9(4-1BB) Reporter Jurkat Cell line

  • For research use only

Cat No.

ABC-RC091F
Product Type

Reporter Stable Cell Lines
Cell Type

T Lymphoblast
Species

Human
Host Cell

Jurkat
Source Organ

Blood
Disease

Acute T Cell Leukemia
Storage

Liquid Nitrogen

TNFRSF9(4-1BB) Reporter Jurkat Cell line provides an immunology model for investigating T-cell activation, checkpoint modulation, and immune response.

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  • TNFRSF9(4-1BB) Reporter Jurkat Cell line
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Home | Transfected Stable Cell Lines | Reporter Stable Cell Lines | TNFRSF9(4-1BB) Reporter Jurkat Cell line

Description

4-1BB, also known as CD137 or TNFRSF9, is an inducible costimulatory receptor belonging to the tumor necrosis factor receptor superfamily. It is expressed in T cells, natural killer (NK) cells, and innate immune cells. Interaction between 4-1BB and its ligand (4-1BBL) promotes cell proliferation, survival, and cytokine production. Currently, drug development targeting 4-1BB is primarily for treating inflammation, autoimmune diseases, and cancer. Agonistic antibodies targeting 4-1BB have shown promising results in treating inflammation and autoimmune diseases. Combining therapies targeting 4-1BB with immune checkpoints or costimulatory targets will enhance anti-tumor effects.TNFRSF9 (4-1BB) Reporter Jurkat cell line is a luciferase reporter gene cell line constructed based on 4-1BBL/4-1BB. These cells stably express the 4-1BB gene and the luciferase reporter gene, which can be used to evaluate the in vitro activation effects of therapeutic antibodies targeting 4-1BB.The TNFRSF9 (4-1BB) Reporter Jurkat Cell Line can be used in combination with the FCGR2B CHO-K1 Cell Line to assess the interaction between antibodies and the FcγRIIb receptor when crosslinked, evaluating the in vitro activation effects of antibodies.

Species

Human
Cat.No

ABC-RC091F
Quality Control

All cells test negative for mycoplasma, bacteria, yeast, and fungi.
Product Category Transfected Stable Cell Lines
Size/Quantity

1 vial
Cell Type

T Lymphoblast
Growth Mode

Suspension
Shipping Info

Dry Ice
Growth Conditions

37 ℃, 5% CO2
Source Organ

Blood
Disease

Acute T Cell Leukemia
Biosafety Level

1
Storage

Liquid Nitrogen
Product Type

Reporter Stable Cell Lines
Host Cell

Jurkat

Application

  • For research use only

Citation

When you publish your research, please cite our product as “AcceGen Biotech Cat.# XXX-0000”. In return, we’ll give you a $100 coupon. Simply click here and submit your paper’s PubMed ID (PMID).

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To succeed in cell culture
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To support a consistent result
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