4T1/STAT5 Reporter (Luc) Stable Cell Line

Description

4T1/STAT5 Reporter (Luc) stable Cell Line is a genetically engineered murine mammary carcinoma model derived from the 4T1 parental cell line, designed for monitoring STAT5 (Signal Transducer and Activator of Transcription 5) signaling activity through luciferase (Luc) reporter expression. This adherent epithelial cell line stably integrates a STAT5-responsive luciferase construct, enabling sensitive quantification of STAT5 pathway activation via bioluminescence. The cells maintain native 4T1 characteristics including high metastatic potential and tumorigenicity, while providing a robust tool for studying STAT5-mediated gene regulation. Key applications include high-throughput drug screening, mechanistic studies of STAT5-dependent processes, and evaluation of therapeutic candidates targeting this pathway. The cell line is maintained at low passages (<P20) to ensure genetic stability and consistent reporter performance. The cells have undergone rigorous quality control testing and are confirmed free of contamination from mycoplasma, fungi, yeast, and bacteria.