B6129SF2/J Mouse Kidney Cells

Description

B6129SF2/J Mouse Kidney Cells are primary cells isolated from the renal cortex of B6129SF2/J mice. These cells comprise a heterogeneous population, including proximal tubule epithelial cells (PT), podocytes, and distal convoluted tubule cells (DCT), which are critical for ion transport, metabolic waste filtration, and electrolyte homeostasis, making them suitable for B6129SF2/J kidney model research. Studies demonstrate their involvement in nephrotoxicity models, such as cisplatin-induced acute kidney injury, where PT cells exhibit heightened susceptibility to toxicants due to high metabolic activity. They express kidney-specific markers such as AQP1 and E-cadherin and are suitable for studying nephron-associated processes. In vitro, these cells show limited proliferative capacity; repeated freeze-thaw cycles must be avoided to preserve viability. Each lot undergoes rigorous screening and isolation procedures, and is rigorously tested to ensure it is free of contamination from Mycoplasma, Fungi, Yeast, and Bacteria.