BALB/c Mouse Alveolar Epithelial Cells

Description

BALB/c Mouse Alveolar Epithelial Cells are freshly isolated from the lung tissue of pathogen-free BALB/c mice, yielding a mixed population of alveolar type I and type II cells. These cells are useful for modeling lung injury, infection, and repair. Primary type II cells, marked by LBP180/SP-C expression, can be maintained in culture for over a week before differentiating into type I-like cells expressing specific phenotypic markers. These cells feature characteristic epithelial morphology and tight junction protein expression (e.g., ZO-1 and E-cadherin). They express surfactant proteins and tight junction components critical for alveolar barrier function. Cryopreserved at early passages, they retain physiological functions like surfactant production, monolayer formation, and barrier integrity, making them suitable for mechanistic lung biology studies. Each lot undergoes rigorous screening and isolation procedures, and is rigorously tested to ensure it is free of contamination from Mycoplasma, Fungi, Yeast, and Bacteria.