BALB/c Mouse Aortic Endothelial Cells

Description

BALB/c Mouse Aortic Endothelial Cells are primary cells isolated from the thoracic aorta of BALB/c mice, a widely used inbred strain in cardiovascular and immunological research. These cells exhibit the classic cobblestone morphology of endothelial monolayers and express markers such as CD31 (PECAM-1) and von Willebrand factor. Functionally, they maintain critical roles in vascular homeostasis, including nitric oxide production, selective permeability, leukocyte adhesion, and the remodeling of BALB/c vascular endothelial extracellular matrix. These cells are particularly relevant for studying endothelial responses to oxidative stress, inflammation, and shear stress—factors central to atherosclerosis and vascular aging. They are non-transformed and have limited proliferative capacity; repeated freeze-thaw cycles should be avoided to preserve viability. Each lot undergoes rigorous screening and isolation procedures, and is rigorously tested to ensure it is free of contamination from Mycoplasma, Fungi, Yeast, and Bacteria.