BALB/c Mouse Aortic Fibroblasts

Description

BALB/c Mouse Aortic Fibroblasts are primary cells isolated from the aortic tissue of BALB/c mice. These fibroblasts exhibit a spindle-shaped morphology and adhere tightly to culture surfaces. As key structural components of the aortic wall, aortic fibroblasts play essential roles in extracellular matrix (ECM) synthesis, collagen turnover, and vascular remodeling. Under pathological conditions such as hypertension or atherosclerosis, they can transdifferentiate into myofibroblasts, contributing to vascular stiffening and fibrosis. These cells are typically characterized by expression of vimentin and α-SMA, and they respond to mechanical stress and cytokine signaling. The cells are cryopreserved at early passage and have limited proliferative capacity in vitro. They play a key role in vascular remodeling and fibrosis under pathological stimuli. Each lot undergoes rigorous screening and isolation procedures, and is rigorously tested to ensure it is free of contamination from Mycoplasma, Fungi, Yeast, and Bacteria.