BALB/c Mouse Cardiac Endothelial Cells

Description

BALB/c Mouse Cardiac Endothelial Cells (cMVECs) are isolated from the cardiac tissue of BALB/c mice. These primary cells form a monolayer of flat epithelial cells lining the cardiac microvasculature and play critical roles in regulating vascular tension, blood pressure, and thrombosis prevention. Functionally, they are implicated in cardiovascular pathologies such as viral myocarditis (e.g., Coxsackievirus B3 infection) and myocardial fibrosis, where endothelial activation drives inflammation and tissue remodeling. The cells exhibit a cobblestone or irregular elongated morphology and adhere tightly to culture surfaces. They are identified by high CD31 expression. cMVECs have limited proliferative capacity in vitro; they are cryopreserved post-isolation to maintain viability. These cells also contribute to nitric oxide production and vascular homeostasis, essential for studying endothelial dysfunction in cardiac diseases. Each lot undergoes rigorous screening and isolation procedures, and is rigorously tested to ensure it is free of contamination from Mycoplasma, Fungi, Yeast, and Bacteria.