BALB/c Mouse Dermal Lymphatic Endothelial Cells

Description

BALB/c Mouse Dermal Lymphatic Endothelial Cells (LECs) are primary cells isolated from the dermal tissue of pathogen-free BALB/c mice, making them an ideal model for strain specific dermal lymphatic endothelial cells studies. These cells exhibit typical endothelial morphology and function as key regulators of lymphangiogenesis, immune cell trafficking, and interstitial fluid drainage. They express specific markers such as podoplanin (PDPN), a transmembrane glycoprotein critical for lymphatic endothelial adhesion, migration, and tube formation. Studies highlight their role in skin inflammation models, including atopic dermatitis (AD), where they contribute to pathological Th2 cytokine responses (e.g., elevated IL-4/IL-5) and IgE-mediated hypersensitivity. Karyotype analysis confirms the chromosomal stability of BALB/c Mouse Dermal Lymphatic Endothelial Cells. These cells have limited proliferative capacity and cannot be passaged extensively. Each lot undergoes rigorous screening and isolation procedures, and is rigorously tested to ensure it is free of contamination from Mycoplasma, Fungi, Yeast, and Bacteria.