For research use only
| Cat No. | ABC-TC0098 |
| Product Type | Human Uterine Cancer Cell Lines |
| Cell Type | Epithelial |
| Species | Human |
| Growth Conditions | 37 ℃, 5% CO2 |
| Source Organ | Cervix |
| Disease | Cervical Cancer |
| Product Code | C-4 I; C-4-i; C4-I; C4-1; C4 I; C4I; C41; Hs 636.T; Hs 636 T |
Human Caucasian Cervical carcinoma. Established from a cervical carcinoma of a 41 year old Caucasian female.
C-4I is a human cervical squamous carcinoma cell line derived from a 41-year-old Caucasian female patient. It exhibits tightly adherent, stratified epithelial colonies and retains squamous differentiation during long-term culture. Cytogenetic analysis confirms a hypodiploid karyotype containing integrated HPV-18 DNA, with specific chromosomal abnormalities including der(8)t(8q;12q), der(18)t(18q;?), and loss of chromosomes 15 and 18. Additionally, C-4I retains two normal copies of chromosome 6. This line expresses epithelial markers, and overexpression of wild-type p53 in C-4I suppresses cell proliferation and tumorigenic potential, highlighting its intact downstream tumor suppressor pathway despite HPV presence. The cells undergo rigorous screening and isolation procedures, and are rigorously tested to ensure they are free of contamination from HIV-1, HBV, HCV, Syphilis, Mycoplasma, Fungi, Yeast, and Bacteria.
| Product Code | C-4 I; C-4-i; C4-I; C4-1; C4 I; C4I; C41; Hs 636.T; Hs 636 T |
| Species | Human |
| Cat.No | ABC-TC0098 |
| Product Category | Tumor Cell Lines |
| Size/Quantity | 1 vial |
| Cell Type | Epithelial |
| Growth Mode | Adherent |
| Shipping Info | Dry Ice |
| Growth Conditions | 37 ℃, 5% CO2 |
| Source Organ | Cervix |
| Disease | Cervical Cancer |
| Biosafety Level | 1 |
| Storage | Liquid Nitrogen |
| Product Type | Human Uterine Cancer Cell Lines |
C-4I serves as a robust in vitro model to investigate cervical cancer pathogenesis, including HPV-18-mediated transformation, p53 signaling modulation, and epithelial-to-mesenchymal transition (EMT). In EMT research, its epithelial morphology provides a baseline for comparing mesenchymal traits when treated with stimuli like HGF or AMPK activators. Furthermore, the responsiveness of C-4I to wild-type p53 overexpression provides insights into tumor suppressor reactivation strategies. These features make C-4I a valuable tool for assessing targeted therapies aimed at reversing epithelial dedifferentiation or reactivating tumor suppressive mechanisms.
When you publish your research, please cite our product as “AcceGen Biotech Cat.# XXX-0000”. In return, we’ll give you a $200 coupon. Simply click here and submit your paper’s PubMed ID (PMID).
