C57BL/10J Mouse Bone Marrow Macrophages

Description

C57BL/10J Mouse Bone Marrow Macrophages originate from hematopoietic stem cells and differentiate under the induction of macrophage colony-stimulating factor (M-CSF). Morphologically, these cells exhibit typical macrophage characteristics in vitro, appearing as round or irregular adherent cells with pseudopodia. They express macrophage markers such as F4/80 and CD11b, while secreting both pro-inflammatory cytokines (e.g., TNF-α, IL-6, IL-1β) and anti-inflammatory factors (e.g., IL-10). Functionally, BMMs perform phagocytosis, process and present antigens, and modulate immune signaling pathways as part of innate immune regulation. These cells serve as a model for mouse strain C57BL/10J macrophage studies, supporting investigations into macrophage functions, signaling, and immune regulation. The cells undergo rigorous screening and isolation procedures, and are rigorously tested to ensure they are free of contamination from Mycoplasma, Fungi, Yeast, and Bacteria.