C57BL/10J Mouse Kidney Fibroblasts

Description

C57BL/10J Mouse Kidney Fibroblasts are mainly derived from renal interstitial tissue. Morphologically, these cells usually present a spindle-shaped, star-shaped, or multi-protruding flat shape when cultured in vitro. These cells express fibronectin and vimentin. These molecules are involved in the synthesis and remodeling of the extracellular matrix (ECM), which is essential for maintaining the structural integrity and tissue repair of the kidney. These cells are not only responsible for the balance of ECM production and degradation but also participate in inflammation regulation, tissue repair, and fibrosis. They can interact with immune cells by secreting cytokines (such as IL-6 and TNF-α) to affect the local microenvironment. These cells are widely used in C57BL/10J mouse kidney fibrosis research, helping to elucidate fibroblast remodeling mechanisms and their role in renal tissue homeostasis. Each lot undergoes rigorous screening and isolation procedures, and is rigorously tested to ensure it is free of contamination from Mycoplasma, Fungi, Yeast, and Bacteria.