C57BL/10J Mouse Lung Endothelial Cells

Description

C57BL/10J Mouse Lung Endothelial Cells are primary microvascular endothelial cells isolated from pathogen-free C57BL/10J mouse lungs and are widely used for studying the lung vasculature in C57BL/10J mice. They form tight, cobblestone monolayers and display contact-inhibited growth typical of capillary endothelium. Functionally, they regulate barrier integrity, leukocyte trafficking and angiogenesis, reflecting important functions of lung endothelial cells in mice, and making them valuable for pulmonary vascular studies and disease models such as acute lung injury, pulmonary fibrosis and pulmonary hypertension. They express CD31 (PECAM-1), VE-cadherin (CD144), von Willebrand factor and eNOS. To ensure the quality of these primary cells, repeated freeze-thaw cycles are not recommended due to the fragile nature of these cells. The cells undergo rigorous screening and isolation procedures, and are rigorously tested to ensure they are free of contamination from Mycoplasma, Fungi, Yeast, and Bacteria.