C57BL/6 Mouse Heart Cells

Description

C57BL/6 Mouse Heart Cells are primary cells isolated from the myocardial tissue, endocardial tissue, and epicardial tissue of pathogen-free laboratory mice, serving as a valuable model for the mouse electrocardiography studies. These cells primarily reside within the cardiac tissue compartments of the ventricles, atria, interventricular septum, and valve structures. Following primary culture, these cells are cryopreserved. The cells execute coordinated systolic contraction, electrical conduction, and extracellular matrix (ECM) support via fibroblast-mediated collagen deposition. Studies demonstrate their implication in myocardial infarction, hypertrophic cardiomyopathy (such as MYH7 mutation studies), diabetic cardiomyopathy (like hyperglycemia-induced remodeling), and fibrotic remodeling (like TGF-β-mediated fibroblast activation modeling). Repeated freezing and thawing should be avoided during culture. The cells undergo rigorous screening and isolation procedures, and are rigorously tested to ensure they are free of contamination from Mycoplasma, Fungi, Yeast, and Bacteria.