C57BL/6 Mouse Kidney Glomerular Endothelial Cells

Description

C57BL/6 Mouse Kidney Glomerular Endothelial Cells are primary cells isolated from the kidney tissue of pathogen-free laboratory mice, serving as a critical model for kidney blood filtration in mice and vascular studies in mouse glomeruli. These cells primarily reside within the glomerular capillary tufts. Following primary culture, these cells are cryopreserved. The cells maintain glomerular filtration barrier integrity, regulate vascular tone, and mediate immune cell adhesion. Studies have demonstrated their involvement in diabetic nephropathy, thrombotic microangiopathy, and IgA nephropathy. Phenotypic validation is confirmed by the endothelial markers VE-cadherin, von Willebrand factor (vWF), and CD31/PECAM-1. For optimal performance, repeated freezing and thawing should be avoided during culture. The cells undergo rigorous screening and isolation procedures, and are rigorously tested to ensure they are free of contamination from Mycoplasma, Fungi, Yeast, and Bacteria.