C57BL/6 Mouse Type II Alveolar Epithelial Cells

Description

C57BL/6 Mouse Type II Alveolar Epithelial Cells are primary cells isolated from the lung tissue of C57BL/6 mice. They display irregular shapes and adhere as monolayer clusters on fibronectin-coated surfaces. These cells constituting 2-5% of the alveolar surface area, are cryopreserved after primary culture and typically exhibit limited passaging capacity. Functionally, these cells synthesize and secrete pulmonary surfactants to maintain alveolar stability and fluid homeostasis through active Na+ transport. They also serve as progenitor cells, differentiating into alveolar type I cells to repair epithelial damage.

Application

• C57BL/6 Type II Mouse Alveolar Epithelial Cells are essential tools for in vitro investigations into lung diseases like pulmonary fibrosis and lung injury, offering insights into alveolar epithelium regeneration. With high purity and viability, these cells are suitable for genomic, proteomic analyses, and ex vivo culturing to unravel their contributions across biological processes. They are particularly useful in studying how lung type II mouse alveolar epithelial cell’s innate immune sensing safeguards against viral infections, enhancing our understanding of defense mechanisms against pathogens.