C57BL/6 Mouse Type II Alveolar Epithelial Cells

Description

C57BL/6 Mouse Type II Alveolar Epithelial Cells are primary cells isolated from the lung tissue of C57BL/6 mice, the gold-standard strain for pulmonary research. The cells are cryopreserved after primary culture and typically exhibit limited passaging capacity. They constituting 2-5% of the alveolar surface area. These cuboidal, surfactant-producing cells express hallmark markers like pro-SP-C, SP-B, ABCA3, and LAMP3, and function as progenitors for Type I alveolar cells (AT1) during lung repair. AT2 cells exhibit lamellar body structures visible under electron microscopy, essential for surfactant storage and secretion. They play critical roles in maintaining alveolar integrity, immune modulation, and regeneration and are central to studying pulmonary fibrosis, acute respiratory distress syndrome (ARDS), COPD, and surfactant deficiency disorders. Their ability to self-renew and differentiate makes them invaluable for lung stem cell biology research.