Canine Hepatic Stellate Cells

Description

Canine Hepatic Stellate Cells are isolated from canine liver tissue. Hepatic stellate cells are liver-resident mesenchymal cells that are primarily involved in extracellular matrix production and regulation of liver fibrosis. Following primary culture, these cells are cryopreserved for research purposes. Hepatic stellate cells become activated during liver injury and contribute to collagen deposition, inflammatory signaling, and tissue remodeling. These cells are reported to express stellate cell-associated markers including α-SMA, desmin, and GFAP. In vitro, they exhibit adherent growth and display a spindle-shaped fibroblast-like morphology. Canine hepatic stellate cells are widely used in studies of hepatic fibrosis, toxicology, liver injury, and regenerative medicine. Each lot undergoes rigorous screening and isolation procedures, and is rigorously tested to ensure it is free of contamination from mycoplasma, fungi, yeast, and bacteria.