For research use only
| Cat No. | ABC-TC0114 |
| Product Type | Human Ovarian Cancer Cell Lines |
| Cell Type | Epithelial |
| Species | Human |
| Growth Conditions | 37 ℃, 5% CO2 |
| Source Organ | Ovary |
| Disease | Adenocarinoma |
| Product Code | CaOv-3; CaOV-3; CAOV-3; CAOV3; CaOV3; CaOv3; Caov3; CA-OV-3 |
Organ: ovary Disease: adenocarcinoma
Caov-3 is a human ovarian high-grade serous adenocarcinoma cell line established from a primary tumor in a 54-year-old Caucasian female patient. These cells feature classic epithelial morphology, forming tightly packed colonies under adherent culture conditions. Genetically, Caov-3 harbors a nonsense mutation in the TP53 tumor suppressor gene, lacks detectable p53 protein, and exhibits amplification of the PIK3CA oncogene. Although these cells fail to grow in soft agar, they are tumorigenic when implanted into immunodeficient mice, confirming their in vivo tumorigenicity. Cytogenetic analyses reveal chromosomal aberrations, typical of ovarian carcinoma. The cells undergo rigorous screening and isolation procedures, and are rigorously tested to ensure they are free of contamination from HIV-1, HBV, HCV, Syphilis, Mycoplasma, Fungi, Yeast, and Bacteria.
| Product Code | CaOv-3; CaOV-3; CAOV-3; CAOV3; CaOV3; CaOv3; Caov3; CA-OV-3 |
| Species | Human |
| Cat.No | ABC-TC0114 |
| Product Category | Tumor Cell Lines |
| Size/Quantity | 1 vial |
| Cell Type | Epithelial |
| Growth Mode | Adherent |
| Shipping Info | Dry Ice |
| Growth Conditions | 37 ℃, 5% CO2 |
| Source Organ | Ovary |
| Disease | Adenocarinoma |
| Biosafety Level | 1 |
| Storage | Liquid Nitrogen |
| Product Type | Human Ovarian Cancer Cell Lines |
Caov-3 cells are employed as a robust in vitro model for high-grade serous ovarian cancer (HGSOC) studies. They are particularly useful in investigating tumor-associated antigen expression, dissecting p53 and PI3K pathway mechanisms, and in drug response research. They show sensitivity to chemotherapeutics including cisplatin, vinblastine, and adriamycin, enabling evaluation of chemosensitivity and resistance.
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