CD-1 Mouse Renal Tubular Epithelial Cells

Description

CD-1 Mouse Renal Tubular Epithelial Cells are isolated from the renal cortex of healthy CD-1 mice. These primary cells represent a crucial component of the nephron, forming the lining of the renal tubules responsible for reabsorption and secretion. Following isolation, the cells are cryopreserved at early passage to maintain their physiological integrity and phenotypic stability. Morphologically, they display a cobblestone-like epithelial appearance and grow as an adherent monolayer. These cells express key markers of tubular epithelium, including E-cadherin and Aquaporin-1, and retain essential functions such as electrolyte transport and response to nephrotoxic stimuli. CD-1 renal tubular epithelial cells have been used to investigate mechanisms of acute kidney injury (AKI), ischemia-reperfusion injury, and drug-induced nephrotoxicity. Repeated freeze-thaw cycles should be avoided to prevent loss of viability and function. Each lot undergoes rigorous screening and isolation procedures, and is rigorously tested to ensure it is free of contamination from Mycoplasma, Fungi, Yeast, and Bacteria.