CD57 Mouse Astrocytes

Description

CD57 Mouse Astrocytes are isolated from the cerebral cortex of neonatal C57BL/6 mice. Cells are derived from healthy neonatal mice with no known neurological defects. Astrocytes are the predominant glial cell type in the central nervous system (CNS), playing crucial roles in maintaining brain homeostasis, regulating synaptic transmission, and supporting neuronal survival. Morphologically, they exhibit a stellate or polygonal shape with extensive branching processes and grow in a monolayer pattern. In vitro, C57BL/6 astrocytes typically show limited proliferative capacity and are not recommended for passaging beyond early passages to preserve physiological characteristics. These astrocytes express glial fibrillary acidic protein (GFAP) and S100β. Importantly, primary mouse astrocytes are widely used in models of neuroinflammation, ischemic stroke, and neurodegenerative disorders such as Alzheimer’s and Parkinson’s disease. These cells exhibit slow proliferation and are not immortalized. Each lot undergoes rigorous screening and isolation procedures, and is rigorously tested to ensure it is free of contamination from Mycoplasma, Fungi, Yeast, and Bacteria.