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Tumor Cell Lines

COR-L23

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Human Caucasian lung large cell carcinoma. Derived from the pleural effusion of a 62-year-old Caucasian male. The cells are tumorigenic in nude mice.
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Product Code

CORL23; COR-L23P; COR-L23/P; L23/P

Species

Human

Cat.No

ABC-TC0179

Product Category Tumor Cell Lines
Size/Quantity

1 vial

Cell Type

Epithelial

Shipping Info

Dry Ice

Growth Conditions

37 ℃, 5% CO2

Source Organ

Lung

Disease

Lung Large Cell Cancer

Biosafety Level

1

Storage

Liquid Nitrogen

Product Type

Human Lung Cancer Cell Lines

Description

COR-L23 cells
COR-L23 is a human large cell undifferentiated lung carcinoma cell line that was originally established in 1985 from the pleural effusion of a 62-year-old Caucasian male patient diagnosed with giant cell anaplastic carcinoma of the lung. COR-L23 exhibits epithelial morphology and adherent culture properties. The karyotype of this cell line is less complex and harbours two translocations. COR-L23 is characterized by c-myc amplification and a KRAS mutation. This cell line is tumorigenic, forming tumors in nude mice.
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Citation

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Application

  • COR-L23 is a human lung cancer cell line widely applied in drug development. It is used to evaluate the effects of interferons, such as alpha and recombinant gamma IFNs, on lung cancer cell growth. It also plays a critical role in studying the multidrug resistance-associated protein (MRP) gene, aiding in the development of therapies aimed at overcoming chemoresistance in lung tumors.

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