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| Product Code | Cos-7; COS 7; Cos 7; COS7; Cos7; CV-1 in Origin Simian-7 |
| Species | Cercopithecus Aethiops |
| Cat.No | ABC-TC0190 |
| Product Category | Tumor Cell Lines |
| Size/Quantity | 1 vial |
| Cell Type | Fibroblast-like |
| Shipping Info | Dry Ice |
| Growth Conditions | 37 ℃, 5% CO2 |
| Source Organ | Kidney |
| Biosafety Level | 1 |
| Storage | Liquid Nitrogen |
| Product Type | Monkey Kidney Cell Lines |
COS-7 is an immortalized fibroblast-like cell line derived from the kidney tissue of the African green monkey (Cercopithecus aethiops). Established in 1981 by Professor Yakov Gluzman, COS-7 cells were created by transforming CV-1 cells with an origin-defective mutant of Simian Virus 40 (SV40) that encodes the wild-type large T-antigen. These cells exhibit adherent growth on glass and plastic surfaces and display a fibroblast-like morphology[].COS-7 cells are widely utilized in molecular biology and virology research due to their ability to support the replication of SV40 and recombinant plasmids containing the SV40 origin of replication . They are particularly valuable for transfection experiments, including the analysis of steroidogenic genes, steroid receptors, and the effects of steroids on gene expression. Regarding safety and quality control, COS-7 cells are confirmed to be negative for common contaminants, including HIV, Hepatitis B, and Hepatitis C viruses.
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COS-7 cells are widely used in research. They are widely utilized for studying SV40 monkey viruses and serve as the commonly used mammalian production cells for producing recombinant proteins such as antibodies and cytokines. The fibroblastic-like growth characteristics of COS-7 cells, combined with their susceptibility to SV40, make them an excellent choice for transfection experiments involving DNA plasmids and mutations to the SV40 virus. Given the potential link between SV40 and human cancers, the continued use of COS-7 cells in SV40-related research provides insights into SV40-associated tumorigenesis.
