Lung fibroblasts are considered as the key effector cells in Idiopathic Pulmonary Fibrosis (IPF), an interstitial lung disease that commonly seen in elderly with unclear etiology. Characterized by excessive fibroproliferation and extracellular matrix accumulation, IPF is associated with progressive decline in lung function, poor diagnosis, and limited treatment option. Studies have suggested that transforming growth factor (TGF)-β induced alveolar epithelial cells (AEC) can undergo epithelial-mesenchymal transition (EMT) and serve as a source of fibroblast or myofibroblast in fibrosis. Aging is also a main contributor to IPF where senescence fibroblasts show abnormal metabolism and senescence-associated secretory phenotypes. Why Choose Diseased Human Lung Fibroblasts, Idiopathic Pulmonary Fibrosis from AcceGen? AcceGen Human lung fibroblasts IPF are derived from patients with idiopathic pulmonary fibrosis. IPF lung fibroblasts are isolated by enzymatic digestion and cryopreserved at passage 2. Each vial contains > 5×10^5 cells in 1 ml volume. Human primary IPF lung fibroblasts are characterized with spindle-shaped morphology and tested negative for von Willebrand factor VIII, cytokeratin 14, 18 and 19, and α-smooth muscle actin. All cells test negative for mycoplasma, bacteria, yeast, and fungi. HIV-1, hepatitis B and hepatitis C are not detected for all donors and/or cell lots.
When you publish your research, please cite our product as “AcceGen Biotech Cat.# XXX-0000”. In return, we’ll give you a $100 coupon. Simply click here and submit your paper’s PubMed ID (PMID).
For research use only Human primary IPF lung fibroblasts provide an excellent in vitro model for studying pathogenesis, etiology and regulation of IPF and other lung diseases that best resemble in vivo conditions. Lung fibroblasts from patients with idiopathic pulmonary fibrosis, differ from lung cells in several aspects, such as proliferation, apoptosis, DNA methylation and miRNA expression.
-Backed by AcceGen advanced technology -Cryopreserved for highest viability and plating efficiency -Quality-tested for accurate results
We know how valuable your research is to you, but are you wondering what you can expect to pay for quick accurate results every time?
Fill out a request in the form below and we’ll get back to you within 24 hours with a quote.
AcceGen is always trying to do right by our customers and working hard to build a higher quality product.