For research use only
| Cat No. | ABC-TC0226 |
| Product Type | Human Prostate Cancer Cell Lines |
| Cell Type | Epithelial |
| Species | Human |
| Growth Conditions | 37 ℃, 5% CO2 |
| Product Code | DU145, DU-145, du 145 |
DU 145 cell line serves as a widely used prostate cancer model for tumor progression, drug screening, and androgen receptor-independent biology.
The DU 145 cell line is a human prostate carcinoma cell line originally isolated from a metastatic brain lesion of a 69-year-old Caucasian male with prostate adenocarcinoma. This cell line exhibits epithelial-like morphology and adherent growth properties. DU 145 is a hypotriploid human cell line with 61–62 chromosomes, exhibiting multiple chromosomal abnormalities, including the absence of chromosome 13 (N13), an abnormally translocated Y chromosome, and a single X chromosome. DU 145 expresses CD44, integrin alpha2 beta1 and CD133. The cell line is tumorigenic in nude mice, forming grade II adenocarcinoma resembling primary prostatic tumors. The cells undergo rigorous screening and isolation procedures, and are rigorously tested to ensure they are free of contamination from HIV-1, HBV, HCV, Syphilis, Mycoplasma, Fungi, Yeast, and Bacteria.
| Product Code | DU145, DU-145, du 145 |
| Species | Human |
| Cat.No | ABC-TC0226 |
| Product Category | Tumor Cell Lines |
| Size/Quantity | 1 vial |
| Cell Type | Epithelial |
| Shipping Info | Dry Ice |
| Growth Conditions | 37 ℃, 5% CO2 |
| Biosafety Level | 1 |
| Storage | Liquid Nitrogen |
| Product Type | Human Prostate Cancer Cell Lines |
DU 145 cells serve as a metastatic prostate adenocarcinoma model to investigate therapy resistance mechanisms and bone tropism in castration-resistant prostate cancer (CRPC). They enable in vitro chemotherapy/radiation response screening and metastasis mechanism studies. This system facilitates androgen receptor (AR)-independent target validation and 3D bone metastasis modeling using mineralized scaffolds, supporting in vitro evaluation of potential therapeutic strategies for advanced CRPC.
When you publish your research, please cite our product as “AcceGen Biotech Cat.# XXX-0000”. In return, we’ll give you a $200 coupon. Simply click here and submit your paper’s PubMed ID (PMID).
Saranyutanon S, Deshmukh SK, Dasgupta S, Pai S, Singh S, Singh AP. Cellular and Molecular Progression of Prostate Cancer: Models for Basic and Preclinical Research. Cancers (Basel). 2020;12(9):2651. Published 2020 Sep 17. doi:10.3390/cancers12092651
