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HighQC™ Human IPSC-Derived Neural Stem Cell MAPT P301L HET

  • For research use only

Cat No.

ABC-SC0074T
Product Type

Human iPSCs
Cell Type

Neural Stem Cell
Species

Human
Growth Conditions

37 ℃, 5% CO2
Source Organ

iPSC
Disease

Normal
Storage

Liquid Nitrogen

HighQC™ Human IPSC-Derived Neural Stem Cell MAPT P301L HET models tauopathy for neurodegeneration research using CRISPR-edited heterozygous P301L mutation.

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  • HighQC™ Human IPSC-Derived Neural Stem Cell MAPT P301L HET
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Home | Stem Cells | Induced Pluripotent Stem Cells (iPSCs) | Induced pluripotent stem cell-Derived cells (iPSC-Derived cells) | HighQC™ Human IPSC-Derived Neural Stem Cell MAPT P301L HET

Description

HighQC™ Human IPSC-Derived Neural Stem Cells-MAPT P301L HET are a human iPSC-derived neural stem cell line with a heterozygous P301L mutation (CCA>CTA) introduced into the MAPT gene using CRISPR-Cas9 gene editing. One allele carries the mutation, and the other remains wild-type. These neural stem cells express typical markers of cortical neural stem and progenitor cells, such as PAX6, FOXG1, and Nestin. These MAPT P301L heterozygous iPSC-Derived NSCs are valuable for investigating targeted interventions at the preclinical stages of tauopathy. The cells undergo rigorous screening and isolation procedures, and are rigorously tested to ensure they are free of contamination from HIV-1, HBV, HCV, Syphilis, Mycoplasma, Fungi, Yeast, and Bacteria.

Product Code

HighQC™ Human IPSC-Derived Neural Stem Cell MAPT P301L HET, hIPSC-NSC-MAPT-P301L-HET, Human IPSC Neural Stem Cells MAPT P301L Heterozygous
Species

Human
Cat.No

ABC-SC0074T
Product Category

Stem Cells
Size/Quantity

1 vial
Cell Type

Neural Stem Cell
Growth Mode

Adherent
Shipping Info

Dry Ice
Growth Conditions

37 ℃, 5% CO2
Source Organ

iPSC
Disease

Normal
Storage

Liquid Nitrogen
Product Type

Human iPSCs

Application

  • This neural stem cell model derived from a heterozygous MAPT P301L iPSC line is used to study tau-driven pathology in a gene-dose-dependent manner. It supports the investigation of altered neuron morphology, tau mislocalization, and neurodegeneration relevant to FTDP-17. Its heterozygous configuration allows for the observation of subtle pathological changes that mirror the early stages of disease progression in human carriers.

Citation

When you publish your research, please cite our product as "AcceGen Biotech Cat.# XXX-0000". In return, we’ll give you a $200 coupon. Simply click here and submit your paper’s PubMed ID (PMID).

Frequently Asked Questions

  • Can MAPT P301L iPSC-derived neural stem cells be used as a tauopathy in vitro model, and do they express TrkB or TrkC?

    Yes. MAPT P301L iPSC-derived neural stem cells can be differentiated into excitatory cortical neurons and are suitable for studies of MAPT-associated neuronal phenotypes and tauopathy in vitro model applications. Following differentiation, the cells express NTRK1, NTRK2 (TrkB), and NTRK3 (TrkC), with functional synaptic activity supported by MEA data. However, tau-related pathological phenotypes have not yet been specifically characterized in this cell line, so validated data on tau pathology or synapse loss are not currently available. A control iPSC-derived neural stem cell line can be provided for comparative studies. This product is available as a custom differentiation project rather than an off-the-shelf product.

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