HighQC™ Human IPSC From LCL-Spondylometaphyseal Displasia, Kozlowski Type

Description

HighQC™ Human IPSC From LCL-Spondylometaphyseal Dysplasia, Kozlowski Type is a disease-specific human induced pluripotent stem cell (iPSC) line. It was generated by reprogramming a lymphoblastoid cell line (LCL) derived from the peripheral blood mononuclear cells (PBMCs) of a donor diagnosed with Spondylometaphyseal Dysplasia, Kozlowski Type, a bone disease characterized by short stature involving the trunk. The reprogramming was performed using non-integrating episomal plasmid method. The resulting iPSCs exhibit adherent growth with a high nucleus-to-cytoplasm ratio. They sustain pluripotency for skeletal development mechanism research. These human iPSCs retain the fundamental capacity for trilineage differentiation into cell types of the ectoderm, mesoderm, and endoderm germ layers. Core pluripotency marker SSEA-4 is expressed. The cells undergo rigorous screening and isolation procedures, and are rigorously tested to ensure they are free of contamination from HIV-1, HBV, HCV, Syphilis, Mycoplasma, Fungi, Yeast, and Bacteria.