For research use only
| Cat No. | ABC-TC0420 |
| Product Type | Human Oral Cancer Cell Lines |
| Cell Type | Epithelial-like |
| Species | Human |
| Growth Conditions | 37 ℃, 5% CO2 |
| Source Organ | Tongue |
| Disease | Tongue Squamous Cell Cancer |
| Product Code | HSC4 |
HSC-4 oral squamous carcinoma cells show epithelial morphology and growth, express epidermal growth factors, used for cancer and drug studies.
The HSC-4 cell line is a human oral squamous cell carcinoma (OSCC) cell derived from a metastatic lesion in the tongue, tissue. These adherent epithelial cells exhibit polygonal morphology and grow in monolayers with cobblestone-like appearance. HSC-4 expresses epithelial markers such as cytokeratin and E-cadherin and shows moderate differentiation. Cytogenetic analyses reveal multiple chromosomal abnormalities, including complex rearrangements common in head and neck cancers. HSC-4 is tumorigenic in immunodeficient mice, forming well-differentiated squamous cell tumors. The cells also display low-to-moderate metastatic potential in vivo, making them suitable for studying localized and early invasive OSCC. It is widely used for studying the molecular mechanisms of squamous cell carcinoma, drug screening, and metastatic invasion behavior.
| Product Code | HSC4 |
| Species | Human |
| Cat.No | ABC-TC0420 |
| Product Category | Tumor Cell Lines |
| Size/Quantity | 1 vial |
| Cell Type | Epithelial-like |
| Shipping Info | Dry Ice |
| Growth Conditions | 37 ℃, 5% CO2 |
| Source Organ | Tongue |
| Disease | Tongue Squamous Cell Cancer |
| Biosafety Level | 1 |
| Storage | Liquid Nitrogen |
| Product Type | Human Oral Cancer Cell Lines |
HSC-4 is widely used in oral cancer research, particularly for exploring the mechanisms of squamous cell carcinoma development, epithelial-mesenchymal transition (EMT), and resistance to chemoradiotherapy. It serves as a valuable platform for screening anti-oral cancer agents and studying tumor invasion, angiogenesis, and interactions with the tumor microenvironment. HSC-4 also supports gene editing and transcriptome analyses in OSCC research.
When you publish your research, please cite our product as “AcceGen Biotech Cat.# XXX-0000”. In return, we’ll give you a $200 coupon. Simply click here and submit your paper’s PubMed ID (PMID).
